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Predictors of life-threatening complications in relatively lower-risk patients hospitalized with COVID-19

Author

Listed:
  • Christopher J Gonzalez
  • Cameron J Hogan
  • Mangala Rajan
  • Martin T Wells
  • Monika M Safford
  • Laura C Pinheiro
  • Arnab K Ghosh
  • Justin J Choi
  • Clare A Burchenal
  • Pooja D Shah
  • Martin F Shapiro

Abstract

Older individuals with chronic health conditions are at highest risk of adverse clinical outcomes from COVID-19, but there is widespread belief that risk to younger, relatively lower-risk individuals is negligible. We assessed the rate and predictors of life-threatening complications among relatively lower-risk adults hospitalized with COVID-19. Of 3766 adults hospitalized with COVID-19 to three hospitals in New York City from March to May 2020, 963 were relatively lower-risk based on absence of preexisting health conditions. Multivariable logistic regression models examined in-hospital development of life-threatening complications (major medical events, intubation, or death). Covariates included age, sex, race/ethnicity, hypertension, weight, insurance type, and area-level sociodemographic factors (poverty, crowdedness, and limited English proficiency). In individuals ≥55 years old (n = 522), 33.3% experienced a life-threatening complication, 17.4% were intubated, and 22.6% died. Among those

Suggested Citation

  • Christopher J Gonzalez & Cameron J Hogan & Mangala Rajan & Martin T Wells & Monika M Safford & Laura C Pinheiro & Arnab K Ghosh & Justin J Choi & Clare A Burchenal & Pooja D Shah & Martin F Shapiro, 2022. "Predictors of life-threatening complications in relatively lower-risk patients hospitalized with COVID-19," PLOS ONE, Public Library of Science, vol. 17(2), pages 1-13, February.
    • Handle: RePEc:plo:pone00:0263995
    DOI: 10.1371/journal.pone.0263995
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