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Predicting factors for the efficacy of cross-linking for keratoconus

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  • Denise Wajnsztajn
  • Or Shmueli
  • Ken Zur
  • Joseph Frucht-Pery
  • Abraham Solomon

Abstract

Purpose: To evaluate predictors for success in corneal crosslinking (CXL) for keratoconus in a large cohort and extended follow-up. Design: A retrospective study based on a prospectively built database. Methods: Participants underwent CXL for keratoconus from 2007 to 2018. Statistical analysis was performed for patients with at least 1-year follow-up. We analyzed effects of CXL type (Epithelium-on or Epithelium-off and Accelerated (9mW/cm2@10min) or Standard (3mW/cm2@30min)) and pre-operative factors including age, gender, baseline LogMAR visual acuity (LogMARpre), maximal corneal power (Kmaxpre), pachymetry, refractive and topographic cylinders, spherical equivalent (SEpre), mean corneal power (MeanK) and follow-up time on outcome measures. The outcome measures were the final change of Kmax (Delta Kmax) and the final change in LogMAR visual acuity (Delta LogMAR). A more negative Delta Kmax or Delta LogMAR represents a favorable effect of crosslinking. Results: 517 eyes had Kmax results, and 385 eyes had LogMAR results with more than one year follow-up. These eyes were included in the study. The mean follow-up time was 2.29 years. Mean Kmax decreased from 54.07±5.99 diopters to 52.84±5.66 diopters (p 65 D or Pachymetry

Suggested Citation

  • Denise Wajnsztajn & Or Shmueli & Ken Zur & Joseph Frucht-Pery & Abraham Solomon, 2022. "Predicting factors for the efficacy of cross-linking for keratoconus," PLOS ONE, Public Library of Science, vol. 17(2), pages 1-19, February.
    • Handle: RePEc:plo:pone00:0263528
    DOI: 10.1371/journal.pone.0263528
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