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Effects of cholesterol on the size distribution and bending modulus of lipid vesicles

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  • Mohammad Abu Sayem Karal
  • Nadia Akter Mokta
  • Victor Levadny
  • Marina Belaya
  • Marzuk Ahmed
  • Md Kabir Ahamed
  • Shareef Ahammed

Abstract

The influence of cholesterol fraction in the membranes of giant unilamellar vesicles (GUVs) on their size distributions and bending moduli has been investigated. The membranes of GUVs were synthesized by a mixture of two elements: electrically neutral lipid 1, 2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and cholesterol and also a mixture of three elements: electrically charged lipid 1,2-dioleoyl-sn-glycero-3-phospho-(1′-rac-glycerol) (DOPG), DOPC and cholesterol. The size distributions of GUVs have been presented by a set of histograms. The classical lognormal distribution is well fitted to the histograms, from where the average size of vesicle is obtained. The increase of cholesterol content in the membranes of GUVs increases the average size of vesicles in the population. Using the framework of Helmholtz free energy of the system, the theory developed by us is extended to explain the experimental results. The theory determines the influence of cholesterol on the bending modulus of membranes from the fitting of the proper histograms. The increase of cholesterol in GUVs increases both the average size of vesicles in population and the bending modulus of membranes.

Suggested Citation

  • Mohammad Abu Sayem Karal & Nadia Akter Mokta & Victor Levadny & Marina Belaya & Marzuk Ahmed & Md Kabir Ahamed & Shareef Ahammed, 2022. "Effects of cholesterol on the size distribution and bending modulus of lipid vesicles," PLOS ONE, Public Library of Science, vol. 17(1), pages 1-24, January.
    • Handle: RePEc:plo:pone00:0263119
    DOI: 10.1371/journal.pone.0263119
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    1. Mohammad Abu Sayem Karal & Tawfika Nasrin & Marzuk Ahmed & Md Kabir Ahamed & Shareef Ahammed & Salma Akter & Sharif Hasan & Zaid Bin Mahbub, 2021. "A new purification technique to obtain specific size distribution of giant lipid vesicles using dual filtration," PLOS ONE, Public Library of Science, vol. 16(7), pages 1-20, July.
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