IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0260458.html
   My bibliography  Save this article

Efficacy and safety of a thermosensitive hydrogel for endoscopic submucosal dissection: An in vivo swine study

Author

Listed:
  • Han Jo Jeon
  • Hyuk Soon Choi
  • Eun Ju Bang
  • Kang Won Lee
  • Sang Hyun Kim
  • Jae Min Lee
  • Eun Sun Kim
  • Bora Keum
  • Yoon Tae Jeen
  • Hong Sik Lee
  • Hoon Jai Chun
  • Seung Jeong
  • Jong Hyuk Kim

Abstract

Injectable thermo-sensitive chitosan hydrogels have recently been developed for the use of submucosal fluids in endoscopic submucosal dissections (ESD). This study aimed to investigate the efficacy and safety of chitosan hydrogels during ESD. Submucosal fluids were administered as follows: 0.9% normal saline (NS), 0.4% hyaluronic acid (HA) and chitosan/β-glycerophosphate (CS/GP) hydrogel. Each solution was administered twice into the stomach and colon of a pig, with a total of 72 ESD procedures performed on 12 pigs. The injected volume and procedure-related parameters were recorded and analyzed. ESDs that created ulcers after 7 days were histologically compared. All ESD specimens were resected en bloc. The total injected volumes during ESD of the stomach (NS, 16.09±3.27 vs. HA, 11.17±2.32 vs. CS/GP, 9.44±2.33; p

Suggested Citation

  • Han Jo Jeon & Hyuk Soon Choi & Eun Ju Bang & Kang Won Lee & Sang Hyun Kim & Jae Min Lee & Eun Sun Kim & Bora Keum & Yoon Tae Jeen & Hong Sik Lee & Hoon Jai Chun & Seung Jeong & Jong Hyuk Kim, 2021. "Efficacy and safety of a thermosensitive hydrogel for endoscopic submucosal dissection: An in vivo swine study," PLOS ONE, Public Library of Science, vol. 16(12), pages 1-12, December.
    • Handle: RePEc:plo:pone00:0260458
    DOI: 10.1371/journal.pone.0260458
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0260458
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0260458&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0260458?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0260458. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.