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Quercetin exhibits potent antioxidant activity, restores motor and non-motor deficits induced by rotenone toxicity

Author

Listed:
  • Syeda Madiha
  • Zehra Batool
  • Saiqa Tabassum
  • Laraib Liaquat
  • Sadia Sadir
  • Sidrah Shahzad
  • Fizza Naqvi
  • Sadia Saleem
  • Sarwat Yousuf
  • Amber Nawaz
  • Saara Ahmad
  • Irfan Sajid
  • Asia Afzal
  • Saida Haider

Abstract

The rotenone-induced animal model of Parkinson’s disease (PD) has been used to investigate the pathogenesis of PD. Oxidative stress is one of the main contributors of neurodegeneration in PD. Flavonoids have the potential to modulate neuronal function and combat various neurodegenerative diseases. The pre- and post-supplementation of quercetin (50 mg/kg, p.o) was done in rats injected with rotenone (1.5 mg/kg, s.c). After the treatment, behavioral activities were monitored for motor activity, depression-like behavior, and cognitive changes. Rats were decapitated after behavioral analysis and the brain samples were dissected out for neurochemical and biochemical estimation. Results showed that supplementation of quercetin significantly (p

Suggested Citation

  • Syeda Madiha & Zehra Batool & Saiqa Tabassum & Laraib Liaquat & Sadia Sadir & Sidrah Shahzad & Fizza Naqvi & Sadia Saleem & Sarwat Yousuf & Amber Nawaz & Saara Ahmad & Irfan Sajid & Asia Afzal & Saida, 2021. "Quercetin exhibits potent antioxidant activity, restores motor and non-motor deficits induced by rotenone toxicity," PLOS ONE, Public Library of Science, vol. 16(11), pages 1-26, November.
    • Handle: RePEc:plo:pone00:0258928
    DOI: 10.1371/journal.pone.0258928
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