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Newborn infant skin gene expression: Remarkable differences versus adults

Author

Listed:
  • Marty O Visscher
  • Ping Hu
  • Andrew N Carr
  • Charles C Bascom
  • Robert J Isfort
  • Kellen Creswell
  • Rachel Adams
  • Jay P Tiesman
  • Karen Lammers
  • Vivek Narendran

Abstract

At birth, human infants are poised to survive in harsh, hostile conditions. An understanding of the state of newborn skin development and maturation is key to the maintenance of health, optimum response to injury, healing and disease. The observational study collected full-thickness newborn skin samples from 27 infants at surgery and compared them to skin samples from 43 adult sites protected from ultraviolet radiation exposure, as the standard for stable, mature skin. Transcriptomics profiling and gene set enrichment analysis were performed. Statistical analysis established over 25,000 differentially regulated probe sets, representing 10,647 distinct genes, in infant skin compared to adult skin. Gene set enrichment analysis showed a significant increase in 143 biological processes (adjusted p

Suggested Citation

  • Marty O Visscher & Ping Hu & Andrew N Carr & Charles C Bascom & Robert J Isfort & Kellen Creswell & Rachel Adams & Jay P Tiesman & Karen Lammers & Vivek Narendran, 2021. "Newborn infant skin gene expression: Remarkable differences versus adults," PLOS ONE, Public Library of Science, vol. 16(10), pages 1-23, October.
    • Handle: RePEc:plo:pone00:0258554
    DOI: 10.1371/journal.pone.0258554
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