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Meta-Analysis illustrates possible role of lipopolysaccharide (LPS)-induced tissue injury in nasopharyngeal carcinoma (NPC) pathogenesis

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  • David Z Allen
  • Jihad Aljabban
  • Dustin Silverman
  • Sean McDermott
  • Ross A Wanner
  • Michael Rohr
  • Dexter Hadley
  • Maryam Panahiazar

Abstract

Background: Nasopharyngeal carcinoma (NPC) is a cancer of epithelial origin with a high incidence in certain populations. While NPC has a high remission rate with concomitant chemoradiation, recurrences are frequent, and the downstream morbidity of treatment is significant. Thus, it is imperative to find alternative therapies. Methods: We employed a Search Tag Analyze Resource (STARGEO) platform to conduct a meta-analysis using the National Center for Biotechnology’s (NCBI) Gene Expression Omnibus (GEO) to define NPC pathogenesis. We identified 111 tumor samples and 43 healthy nasopharyngeal epithelium samples from NPC public patient data. We analyzed associated signatures in Ingenuity Pathway Analysis (IPA), restricting genes that showed statistical significance (p

Suggested Citation

  • David Z Allen & Jihad Aljabban & Dustin Silverman & Sean McDermott & Ross A Wanner & Michael Rohr & Dexter Hadley & Maryam Panahiazar, 2021. "Meta-Analysis illustrates possible role of lipopolysaccharide (LPS)-induced tissue injury in nasopharyngeal carcinoma (NPC) pathogenesis," PLOS ONE, Public Library of Science, vol. 16(10), pages 1-17, October.
    • Handle: RePEc:plo:pone00:0258187
    DOI: 10.1371/journal.pone.0258187
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