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Somatostatin analog therapy effectiveness on the progression of polycystic kidney and liver disease: A systematic review and meta-analysis of randomized clinical trials

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  • Tatsuya Suwabe
  • Francisco J Barrera
  • Rene Rodriguez-Gutierrez
  • Yoshifumi Ubara
  • Marie C Hogan

Abstract

Background: Uncertainty underlies the effectiveness of somatostatin analogues for slowing the progression of polycystic kidney or liver disease. Methods: Eligible studies included randomized controlled trials (RCTs) evaluating somatostatin analog as therapy for patients with polycystic kidney disease (PKD) or polycystic liver disease (PLD) compared to placebo or standard therapy. Two reviewers independently screened studies identified from databases (MEDLINE, EMBASE, Cochrane Database), clinical trial registries, and references from pertinent articles and clinical practice guidelines. Outcome measurements were changes in total liver volume (TLV), total kidney volume (TKV), and estimated glomerular filtration rate (eGFR). Results: Of 264 nonduplicate studies screened, 10 RCTs met the inclusion criteria. The body of evidence provided estimates warranting moderate confidence. Meta-analysis of 7 RCTs including a total of 652 patients showed that somatostatin analogs are associated with a lower %TLV growth rate compared to control (mean difference, -6.37%; 95% CI -7.90 to -4.84, p

Suggested Citation

  • Tatsuya Suwabe & Francisco J Barrera & Rene Rodriguez-Gutierrez & Yoshifumi Ubara & Marie C Hogan, 2021. "Somatostatin analog therapy effectiveness on the progression of polycystic kidney and liver disease: A systematic review and meta-analysis of randomized clinical trials," PLOS ONE, Public Library of Science, vol. 16(9), pages 1-16, September.
    • Handle: RePEc:plo:pone00:0257606
    DOI: 10.1371/journal.pone.0257606
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