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Prognostic value of postoperative decrease in serum albumin on surgically resected early-stage non-small cell lung carcinoma: A multicenter retrospective study

Author

Listed:
  • Fumihiko Kinoshita
  • Tetsuzo Tagawa
  • Takanori Yamashita
  • Tomoyoshi Takenaka
  • Taichi Matsubara
  • Gouji Toyokawa
  • Kazuki Takada
  • Taro Oba
  • Atsushi Osoegawa
  • Koji Yamazaki
  • Mitsuhiro Takenoyama
  • Mototsugu Shimokawa
  • Naoki Nakashima
  • Masaki Mori

Abstract

Background: Preoperative nutritional status is an important host-related prognostic factor for non-small cell lung carcinoma (NSCLC); however, the significance of postoperative changes in nutritional status remains unclear. This study aimed to elucidate the significance of postoperative decreases in serum albumin (ΔAlb) on the outcomes of early-stage NSCLC. Methods: We analyzed 443 training cohort (TC) and 642 validation cohort (VC) patients with pStage IA NSCLC who underwent surgery and did not recur within 1 year. We measured preoperative serum albumin levels (preAlb) and postoperative levels 1 year after surgery (postAlb), and calculated ΔAlb as (preAlb − postAlb)/preAlb × 100%. A cutoff value of 11% for ΔAlb was defined on the basis of the receiver operating characteristic curve for the TC. Results: Patients were divided into ΔAlb-Decreased and ΔAlb-Stable groups, including 100 (22.6%) and 343 (77.4%) in the TC, and 58 (9.0%) and 584 (90.1%) in the VC. ΔAlb-Decreased was associated with male sex (p = 0.0490), smoking (p = 0.0156), and non-adenocarcinoma (p

Suggested Citation

  • Fumihiko Kinoshita & Tetsuzo Tagawa & Takanori Yamashita & Tomoyoshi Takenaka & Taichi Matsubara & Gouji Toyokawa & Kazuki Takada & Taro Oba & Atsushi Osoegawa & Koji Yamazaki & Mitsuhiro Takenoyama &, 2021. "Prognostic value of postoperative decrease in serum albumin on surgically resected early-stage non-small cell lung carcinoma: A multicenter retrospective study," PLOS ONE, Public Library of Science, vol. 16(9), pages 1-14, September.
    • Handle: RePEc:plo:pone00:0256894
    DOI: 10.1371/journal.pone.0256894
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