IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0254640.html
   My bibliography  Save this article

On-admission SARS-CoV-2 RNAemia as a single potent predictive marker of critical condition development and mortality in COVID-19

Author

Listed:
  • Shoji Miki
  • Hiroaki Sasaki
  • Hiroshi Horiuchi
  • Nobuyuki Miyata
  • Yukihiro Yoshimura
  • Kazuhito Miyazaki
  • Takayuki Matsumura
  • Yoshimasa Takahashi
  • Tadaki Suzuki
  • Tetsuro Matano
  • Ai Kawana-Tachikawa
  • Natsuo Tachikawa

Abstract

Background: This study aimed to clarify how SARS-CoV-2 RNAemia is related to COVID-19 critical condition development and mortality in comparison with other predictive markers and scoring systems. Methods: This is a retrospective cohort study conducted at Yokohama Municipal Citizen’s Hospital and National Institute of Infectious Diseases. We recruited adult patients with COVID-19 admitted between March 2020 and January 2021. We compared RNAemia with clinical status on admission including scoring systems such as the 4C Mortality, CURB-65, and A-DROP, as well as the Ct value of the nasopharyngeal PCR, in predicting COVID-19 mortality and critical condition development. Results: Of the 92 recruited patients (median age, 58; interquartile range, 45–71 years), 14 (14.9%) had RNAemia. These patients had an older age (median, 68 years vs. 55.5 years; p = 0.011), higher values of lactated dehydrogenase (median, 381 U/L vs. 256.5 U/L, p

Suggested Citation

  • Shoji Miki & Hiroaki Sasaki & Hiroshi Horiuchi & Nobuyuki Miyata & Yukihiro Yoshimura & Kazuhito Miyazaki & Takayuki Matsumura & Yoshimasa Takahashi & Tadaki Suzuki & Tetsuro Matano & Ai Kawana-Tachik, 2021. "On-admission SARS-CoV-2 RNAemia as a single potent predictive marker of critical condition development and mortality in COVID-19," PLOS ONE, Public Library of Science, vol. 16(7), pages 1-11, July.
    • Handle: RePEc:plo:pone00:0254640
    DOI: 10.1371/journal.pone.0254640
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0254640
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0254640&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0254640?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0254640. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.