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Antirheumatic treatment is associated with reduced serum Syndecan-1 in Rheumatoid Arthritis

Author

Listed:
  • Gia Deyab
  • Trine Marita Reine
  • Tram Thu Vuong
  • Trond Jenssen
  • Gunnbjørg Hjeltnes
  • Stefan Agewall
  • Knut Mikkelsen
  • Øystein Førre
  • Morten Wang Fagerland
  • Svein Olav Kolset
  • Ivana Hollan

Abstract

The endothelial glycocalyx (EG) is essential for proper function of the endothelium and for vascular integrity, but its role in premature atherogenesis in rheumatoid arthritis (RA) has not been studied yet. EG impairment can play a role in pathogenesis of vascular disease, and one of its characteristics is shedding of syndecan-1 from endothelial cells. Syndecan-1 shedding is mediated by matrix metalloproteinase-9 (MMP-9) and counteracted by tissue inhibitor of metalloproteinases (TIMP)-1. Cardiovascular disease risk in RA is reversible by disease modifying antirheumatic drugs (DMARDs), but the exact modes of action are still unclear. Therefore, we examined effects of DMARDs on syndecan-1, MMP-9 and TIMP-1 in RA patients, and searched for associations between these parameters and inflammatory activity. From the observational PSARA study, we examined 39 patients starting with methotrexate (MTX) monotherapy (in MTX naïve patients, n = 19) or tumor necrosis factor inhibitors (TNFi) in combination with MTX (in MTX non-responders, n = 20) due to active RA. Serum syndecan-1, MMP-9 and TIMP-1 were measured at baseline and after six weeks of treatment. Serum syndecan-1 (p = 0.008) and TIMP-1 (p

Suggested Citation

  • Gia Deyab & Trine Marita Reine & Tram Thu Vuong & Trond Jenssen & Gunnbjørg Hjeltnes & Stefan Agewall & Knut Mikkelsen & Øystein Førre & Morten Wang Fagerland & Svein Olav Kolset & Ivana Hollan, 2021. "Antirheumatic treatment is associated with reduced serum Syndecan-1 in Rheumatoid Arthritis," PLOS ONE, Public Library of Science, vol. 16(7), pages 1-11, July.
    • Handle: RePEc:plo:pone00:0253247
    DOI: 10.1371/journal.pone.0253247
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