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Effects of stress associated with academic examination on the kynurenine pathway profile in healthy students

Author

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  • Kyaimon Myint
  • Kelly Jacobs
  • Aye Mu Myint
  • Sau Kuen Lam
  • Lyndal Henden
  • See Ziau Hoe
  • Gilles J Guillemin

Abstract

The effects of stress on the neuroendocrine, central nervous and immune systems are extremely complex. The kynurenine pathway (KP) of the tryptophan metabolism is recognised as a cross-link between the neuroendocrine- and immune systems. However, the effects of acute stress from everyday life on KP activation have not yet been studied. This study aims to investigate changes in the levels of the KP neuroactive metabolites and cytokines in response to stress triggered by academic examinations. Ninety-two healthy first year medical students benevolently participated in the study. Parameters were measured pre- examination, which is considered to be a high-stress period, and post-examination, as a low-stress period. Stress induced by academic examinations significantly increases the perceived stress scores (p

Suggested Citation

  • Kyaimon Myint & Kelly Jacobs & Aye Mu Myint & Sau Kuen Lam & Lyndal Henden & See Ziau Hoe & Gilles J Guillemin, 2021. "Effects of stress associated with academic examination on the kynurenine pathway profile in healthy students," PLOS ONE, Public Library of Science, vol. 16(6), pages 1-15, June.
    • Handle: RePEc:plo:pone00:0252668
    DOI: 10.1371/journal.pone.0252668
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