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Neutrophil-to-lymphocyte ratio associated with an increased risk of mortality in patients with critical limb ischemia

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  • Min-I Su
  • Cheng-Wei Liu

Abstract

Purpose: Association of the neutrophil-to-lymphocyte ratio (NLR) with mortality has not been comprehensively explored in critical limb ischemia (CLI) patients. We investigated the association between the NLR and clinical outcomes in CLI. Materials and methods: We retrospectively enrolled consecutive CLI patients between 1/1/2013 and 12/31/2018. Receiver operating characteristic curve analysis determined NLR cutoffs for 1-year in-hospital, all-cause and cardiac-related mortality; major adverse cardiovascular events (MACEs); and major adverse limb events (MALEs). Results: Among 195 patients (age, 74.0 years, SD: 11.5; 51.8% male; body mass index, 23.4 kg/m2, SD: 4.2), 14.4% exhibited acute limb ischemia. After 1 year, patients with NLR>8 had higher in-hospital mortality (21.1% vs. 3.6%, P

Suggested Citation

  • Min-I Su & Cheng-Wei Liu, 2021. "Neutrophil-to-lymphocyte ratio associated with an increased risk of mortality in patients with critical limb ischemia," PLOS ONE, Public Library of Science, vol. 16(5), pages 1-14, May.
    • Handle: RePEc:plo:pone00:0252030
    DOI: 10.1371/journal.pone.0252030
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