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Prognostic and clinicopathological significance of C-reactive protein/albumin ratio (CAR) in patients with gastric cancer: A meta-analysis

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  • Junhua Yu
  • Huiling Liu
  • Xueyun Zeng
  • Yujun Zhao
  • Dejun Jiang
  • Hang Lu
  • Jun Qian

Abstract

Background: In recent years, many studies have explored the potential prognostic utility of C-reactive protein/albumin ratio (CAR) in patients with gastric cancer (GC), however, the results remain conflicting. We thus performed a meta-analysis to determine the association of CAR and prognosis of GC. Methods: This meta-analysis was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement. PubMed, Web of science, Embase, and Cochrane Library were searched. Hazard ratios (HRs) and 95% confidence intervals (CIs) for overall survival (OS) and cancer-specific survival (CSS) of included studies were pooled to estimate the prognostic value of CAR. Results: Eight studies with a total of 3,216 patients were included in this meta-analysis. High CAR was significantly associated with poor OS (HR = 1.59, 95%CI = 1.36–1.85, p

Suggested Citation

  • Junhua Yu & Huiling Liu & Xueyun Zeng & Yujun Zhao & Dejun Jiang & Hang Lu & Jun Qian, 2021. "Prognostic and clinicopathological significance of C-reactive protein/albumin ratio (CAR) in patients with gastric cancer: A meta-analysis," PLOS ONE, Public Library of Science, vol. 16(4), pages 1-15, April.
    • Handle: RePEc:plo:pone00:0250295
    DOI: 10.1371/journal.pone.0250295
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