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Proteomic identification of biomarkers in maternal plasma that predict the outcome of rescue cerclage for cervical insufficiency

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  • Kisoon Dan
  • Ji Eun Lee
  • Dohyun Han
  • Sun Min Kim
  • Subeen Hong
  • Hyeon Ji Kim
  • Kyo Hoon Park

Abstract

Objective: We sought to identify plasma protein biomarkers that are predictive of the outcome of rescue cerclage in patients with cervical insufficiency. Methods: This retrospective cohort study included 39 singleton pregnant women undergoing rescue cerclage for cervical insufficiency (17–25 weeks) who gave plasma samples. Three sets of pooled plasma samples from controls (cerclage success, n = 10) and cases (cerclage failure, n = 10, defined as spontaneous preterm delivery at

Suggested Citation

  • Kisoon Dan & Ji Eun Lee & Dohyun Han & Sun Min Kim & Subeen Hong & Hyeon Ji Kim & Kyo Hoon Park, 2021. "Proteomic identification of biomarkers in maternal plasma that predict the outcome of rescue cerclage for cervical insufficiency," PLOS ONE, Public Library of Science, vol. 16(4), pages 1-17, April.
    • Handle: RePEc:plo:pone00:0250031
    DOI: 10.1371/journal.pone.0250031
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