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Plasma pentosidine levels are associated with prevalent fractures in patients with chronic liver disease

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  • Chisato Saeki
  • Mitsuru Saito
  • Tomoya Kanai
  • Masanori Nakano
  • Tsunekazu Oikawa
  • Yuichi Torisu
  • Masayuki Saruta
  • Akihito Tsubota

Abstract

Aim: Osteoporotic fractures negatively impact health-related quality of life and prognosis. Advanced glycation end products (AGEs) impair bone quality and reduce bone strength. The aim of this study was to determine the relationship between plasma levels of pentosidine, a surrogate marker for AGEs, and prevalent fractures in patients with chronic liver disease (CLD). Methods: This cross-sectional study included 324 patients with CLD. Vertebral fractures were evaluated using lateral thoracolumbar spine radiographs. Information on prevalent fractures was obtained through a medical interview, medical records, and/or radiography. The patients were classified into low (L), intermediate (I), and high (H) pentosidine (Pen) groups based on baseline plasma pentosidine levels. Results: Of the 324 patients, 105 (32.4%) had prevalent fractures. The prevalence of liver cirrhosis (LC) and prevalent fractures significantly increased stepwise with elevated pentosidine levels. The H-Pen group had the highest prevalence of LC (88.6%, p

Suggested Citation

  • Chisato Saeki & Mitsuru Saito & Tomoya Kanai & Masanori Nakano & Tsunekazu Oikawa & Yuichi Torisu & Masayuki Saruta & Akihito Tsubota, 2021. "Plasma pentosidine levels are associated with prevalent fractures in patients with chronic liver disease," PLOS ONE, Public Library of Science, vol. 16(4), pages 1-14, April.
    • Handle: RePEc:plo:pone00:0249728
    DOI: 10.1371/journal.pone.0249728
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