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Characterizing and quantifying the temporal relationship between structural and functional change in glaucoma

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  • Fang-I Chu
  • Lyne Racette

Abstract

Purpose: To characterize and quantify the temporal relationship between structural and functional change in glaucoma. Methods: 120 eyes of 120 patients with ocular hypertension or primary open-angle glaucoma were selected from the Diagnostic Innovations in Glaucoma Study or the African Descent and Glaucoma Evaluation Study. Patients had 11 visits, separated by at least 3 months over 5 to 10 years. Each visit had rim area (RA) and mean sensitivity (MS) measurements taken within a 30-day period. The structure-function (SF) relationship was summarized using conventional and modified cross-correlation functions (CCFs), which identified the strongest absolute and positive correlation, respectively. Patients were categorized in one of the following three groups: RA and MS evolved simultaneously (lag = 0), RA preceded MS (lag 0). Lagging regression analysis was used to examine the variations of the SF relationship within groups. Results: The number of participants, mean visit lag, and mean correlation (standard deviation) were, for the conventional and modified CCFs, respectively: lag = 0 [16, 0, 0.53 (0.10) and 16, 0, 0.46 (0.11)]; lag 0 [54, 3.35, 0.53 (0.13) and 49, 3.78, 0.45 (0.12)]. A significant difference of the visit lag relation within groups was identified using lagging regression analysis (p

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  • Fang-I Chu & Lyne Racette, 2021. "Characterizing and quantifying the temporal relationship between structural and functional change in glaucoma," PLOS ONE, Public Library of Science, vol. 16(4), pages 1-15, April.
    • Handle: RePEc:plo:pone00:0249212
    DOI: 10.1371/journal.pone.0249212
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