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A systematic review and activation likelihood estimation meta-analysis of the central innervation of the lower urinary tract: Pelvic floor motor control and micturition

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  • Ilse M Groenendijk
  • Ulrich Mehnert
  • Jan Groen
  • Becky D Clarkson
  • Jeroen R Scheepe
  • Bertil F M Blok

Abstract

Purpose: Functional neuroimaging is a powerful and versatile tool to investigate central lower urinary tract (LUT) control. Despite the increasing body of literature there is a lack of comprehensive overviews on LUT control. Thus, we aimed to execute a coordinate based meta-analysis of all PET and fMRI evidence on descending central LUT control, i.e. pelvic floor muscle contraction (PFMC) and micturition. Materials and methods: A systematic literature search of all relevant libraries was performed in August 2020. Coordinates of activity were extracted from eligible studies to perform an activation likelihood estimation (ALE) using a threshold of uncorrected p

Suggested Citation

  • Ilse M Groenendijk & Ulrich Mehnert & Jan Groen & Becky D Clarkson & Jeroen R Scheepe & Bertil F M Blok, 2021. "A systematic review and activation likelihood estimation meta-analysis of the central innervation of the lower urinary tract: Pelvic floor motor control and micturition," PLOS ONE, Public Library of Science, vol. 16(2), pages 1-23, February.
    • Handle: RePEc:plo:pone00:0246042
    DOI: 10.1371/journal.pone.0246042
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