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Predictors of serological cure after penicillin therapy in HIV-negative patients with early syphilis in Shenzhen, China

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  • Zhenzhou Luo
  • Yi Ding
  • Jun Yuan
  • Lishan Tian
  • Li Zhang
  • Qiuhong Wu
  • Jinsong Mou

Abstract

Background: Syphilis is a common infectious disease worldwide. Serological monitoring is important for syphilis management. We currently know little about the characteristics of this seronegative response. The aim of this study was to explore the factors associated with serological cure after treatment of early syphilis. Methods: A retrospective cohort study was conducted and the data of patients with early syphilis in a clinic in Shenzhen from 2011 to 2019 were retrieved. Univariable and multiple Cox proportional hazard regression models were utilized to identify factors associated with a serological cure state among syphilis patients with early syphilis two years after treatment. Results: A total of 346 (85.9%) syphilis patients achieved serological cure. The multivariate analysis results revealed that having a baseline TRUST titer >1:8 was associated with an increased probability of serological cure, compared with having a baseline TRUST titer ≤1:8 (HR = 1.43, 95% CI = 1.10–1.85, P

Suggested Citation

  • Zhenzhou Luo & Yi Ding & Jun Yuan & Lishan Tian & Li Zhang & Qiuhong Wu & Jinsong Mou, 2021. "Predictors of serological cure after penicillin therapy in HIV-negative patients with early syphilis in Shenzhen, China," PLOS ONE, Public Library of Science, vol. 16(1), pages 1-8, January.
    • Handle: RePEc:plo:pone00:0245812
    DOI: 10.1371/journal.pone.0245812
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