IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0245741.html
   My bibliography  Save this article

The safety and efficacy of doxazosin in medical expulsion therapy for distal ureteric calculi: A meta-analysis

Author

Listed:
  • Baozhong Yu
  • Xiang Zheng
  • Zejia Sun
  • Peng Cao
  • Jiandong Zhang
  • Zihao Gao
  • Haoyuan Cao
  • Feilong Zhang
  • Wei Wang

Abstract

Purpose: Alpha-adrenergic receptor blockers can be effectively used in the context of medical expulsion therapy (MET) to treat ureteric stones. This study was designed to evaluate the safety and efficacy of doxazosin in MET relative to placebo or tamsulosin. Methods: We systematically searched the PubMed, the Cochrane Library, EMBASE, Chinese Academic Database, and Web of Science databases to select randomized controlled trials (RCT) that compared the use of doxazosin with placebo or tamsulosin to treat ureteric stones. All patients we included were limited to those diagnosed with visible stones in the distal ureter. The diameter of ureteric stones does not exceed 10 mm. Results: Eight trials comparing doxazosin with placebo or tamsulosin containing 667 patients were assessed in the final analysis. The meta-analysis showed that doxazosin effectively treated ureteric stones and was better than placebo in terms of efficacy. Relative to the placebo group, the expulsion rate of stones from the distal ureter (OR = 3.00, 95% CI [2.15, 4.19], I2 = 0%, P

Suggested Citation

  • Baozhong Yu & Xiang Zheng & Zejia Sun & Peng Cao & Jiandong Zhang & Zihao Gao & Haoyuan Cao & Feilong Zhang & Wei Wang, 2021. "The safety and efficacy of doxazosin in medical expulsion therapy for distal ureteric calculi: A meta-analysis," PLOS ONE, Public Library of Science, vol. 16(1), pages 1-12, January.
    • Handle: RePEc:plo:pone00:0245741
    DOI: 10.1371/journal.pone.0245741
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0245741
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0245741&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0245741?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0245741. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.