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Pentraxin 3 is more accurate than C-reactive protein for Takayasu arteritis activity assessment: A systematic review and meta-analysis

Author

Listed:
  • Xiaoting Wen
  • Ruihong Hou
  • Ke Xu
  • Yunxia Han
  • Junping Hu
  • Yan Zhang
  • Yazhen Su
  • Jinfang Gao
  • Gailian Zhang
  • Liyun Zhang

Abstract

Aims: Whether the circulating levels of pentraxin 3 (PTX3), an acute phase reactant (APR), are higher in active Takayasu arteritis (TAK), and if so, whether PTX3 is more accurate than C-reactive protein (CRP) in TAK activity assessment has been investigated in this study. Study design: Research works such as PubMed, Embase, ScienceDirect, Cochrane Library, and two Chinese literature databases (CNKI and WanFang) were searched for studies conducted till August 30th, 2019. Two investigators searched the studies independently, who evaluated the quality of the study using the Newcastle–Ottawa scale (NOS) and extracted data. Pooled standard mean difference (SMD) and diagnostic indexes, with a 95% confidence interval (CI), were calculated using a random-effect model. Results: Totally, 8 studies involving 473 TAK (208 active and 265 inactive TAK) patients and 252 healthy controls were eventually included in the meta-analysis. PTX3 level in the blood in active TAK patients were found to be higher than that in dormant TAK with pooled SMD of 0.761 (95% CI = 0.38–1.14, p

Suggested Citation

  • Xiaoting Wen & Ruihong Hou & Ke Xu & Yunxia Han & Junping Hu & Yan Zhang & Yazhen Su & Jinfang Gao & Gailian Zhang & Liyun Zhang, 2021. "Pentraxin 3 is more accurate than C-reactive protein for Takayasu arteritis activity assessment: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 16(2), pages 1-11, February.
    • Handle: RePEc:plo:pone00:0245612
    DOI: 10.1371/journal.pone.0245612
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