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Comparing the Voets equation and the Adrogue-Madias equation for predicting the plasma sodium response to intravenous fluid therapy in SIADH patients

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  • Philip J G M Voets
  • Nils P J Vogtländer
  • Karin A H Kaasjager

Abstract

Background: The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is one of the most common causes of hypotonic hyponatremia. In our previous work, we have derived a novel model (Voets equation) that can be used by clinicians to predict the effect of crystalloid intravenous fluid therapy on the plasma sodium concentration in SIADH. Methods: In this retrospective chart review, the predictive accuracy of the Voets equation and the Adrogue-Madias equation for the plasma sodium response to crystalloid infusate was compared for fifteen plasma sodium response measurements (n = 15) in twelve SIADH patients. The medical records of these patients were accessed anonymously and none of the authors were their treating physicians. The Pearson correlation coefficient r and corresponding p-value were calculated for the predictions by the Voets model compared to the measured plasma sodium response and for the predictions by the Adrogue-Madias model compared to the measured plasma sodium response. Results and conclusion: The presented results show that the Voets model (r = 0.94, p

Suggested Citation

  • Philip J G M Voets & Nils P J Vogtländer & Karin A H Kaasjager, 2021. "Comparing the Voets equation and the Adrogue-Madias equation for predicting the plasma sodium response to intravenous fluid therapy in SIADH patients," PLOS ONE, Public Library of Science, vol. 16(1), pages 1-8, January.
    • Handle: RePEc:plo:pone00:0245499
    DOI: 10.1371/journal.pone.0245499
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