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Incorporating radiomic feature of pretreatment 18F-FDG PET improves survival stratification in patients with EGFR-mutated lung adenocarcinoma

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  • Yu-Hung Chen
  • Tso-Fu Wang
  • Sung-Chao Chu
  • Chih-Bin Lin
  • Ling-Yi Wang
  • Kun-Han Lue
  • Shu-Hsin Liu
  • Sheng-Chieh Chan

Abstract

Background: To investigate the survival prognostic value of the radiomic features of 18F-FDG PET in patients who had EGFR (epidermal growth factor receptor) mutated lung adenocarcinoma and received targeted TKI (tyrosine kinase inhibitor) treatment. Methods: Fifty-one patients with stage III-IV lung adenocarcinoma and actionable EGFR mutation who received first-line TKI were retrospectively analyzed. All patients underwent pretreatment 18F-FDG PET/CT, and we calculated the PET-derived radiomic features. Cox proportional hazard model was used to examine the association between the radiomic features and the survival outcomes, including progression-free survival (PFS) and overall survival (OS). A score model was established according to the independent prognostic predictors and we compared this model to the TNM staging system using Harrell's concordance index (c-index). Results: Forty-eight patients (94.1%) experienced disease progression and 41 patients (80.4%) died. Primary tumor SUV entropy > 5.36, and presence of pleural effusion were independently associated with worse OS (both p

Suggested Citation

  • Yu-Hung Chen & Tso-Fu Wang & Sung-Chao Chu & Chih-Bin Lin & Ling-Yi Wang & Kun-Han Lue & Shu-Hsin Liu & Sheng-Chieh Chan, 2020. "Incorporating radiomic feature of pretreatment 18F-FDG PET improves survival stratification in patients with EGFR-mutated lung adenocarcinoma," PLOS ONE, Public Library of Science, vol. 15(12), pages 1-18, December.
    • Handle: RePEc:plo:pone00:0244502
    DOI: 10.1371/journal.pone.0244502
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