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A cohort study of 676 patients indicates D-dimer is a critical risk factor for the mortality of COVID-19

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  • Yongsheng Huang
  • Xiaoyu Lyu
  • Dan Li
  • Lin Wang
  • Yujun Wang
  • Wenbin Zou
  • Yingxin Wei
  • Xiaowei Wu

Abstract

Coronavirus Disease 2019 (COVID-19) has recently become a public emergency and a worldwide pandemic. However, the information on the risk factors associated with the mortality of COVID-19 and of their prognostic potential is limited. In this retrospective study, the clinical characteristics, treatment and outcome data were collected and analyzed from 676 COVID-19 patients stratified into 140 non-survivors and 536 survivors. We found that the levels of Dimerized plasmin fragment D (D-dimer), C-reactive protein (CRP), lactate dehydrogenase (LDH), procalcitonin (PCT) were significantly higher in non-survivals on admission (non-survivors vs. survivors: D-Dimer ≥ 0.5 mg/L, 83.2% vs. 44.9%, P

Suggested Citation

  • Yongsheng Huang & Xiaoyu Lyu & Dan Li & Lin Wang & Yujun Wang & Wenbin Zou & Yingxin Wei & Xiaowei Wu, 2020. "A cohort study of 676 patients indicates D-dimer is a critical risk factor for the mortality of COVID-19," PLOS ONE, Public Library of Science, vol. 15(11), pages 1-11, November.
    • Handle: RePEc:plo:pone00:0242045
    DOI: 10.1371/journal.pone.0242045
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    1. Brandi N. Williamson & Friederike Feldmann & Benjamin Schwarz & Kimberly Meade-White & Danielle P. Porter & Jonathan Schulz & Neeltje Doremalen & Ian Leighton & Claude Kwe Yinda & Lizzette Pérez-Pérez, 2020. "Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2," Nature, Nature, vol. 585(7824), pages 273-276, September.
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