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Treatment outcomes of Nigerian patients with tuberculosis: A retrospective 25-year review in a regional medical center

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  • Michael A Alao
  • Stacene R Maroushek
  • Yiong Huak Chan
  • Adanze O Asinobi
  • Tina M Slusher
  • Daniel A Gbadero

Abstract

Introduction: Tuberculosis (TB) remains a global health challenge and leading infectious killer worldwide. The need for continuous evaluation of TB treatment outcomes becomes more imperative in the midst of a global economic meltdown substantially impacting resource-limited-settings. Methods: This study retrospectively reviewed 25-years of treatment outcomes in 3,384 patients who were managed for TB at a tertiary hospital in Nigeria. Confirmed TB cases were given directly observed therapy of a short-course treatment regimen and monitored for clinical response. Results: Out of 1,146,560 patients screened, there were 24,330 (2.1%) presumptive and 3,384 (13.9%) confirmed TB cases. The patients’ mean age was 35.8 years (0.33–101 years). There were 1,902 (56.2%) male, 332(9.8%) pediatric, and 2,878 (85%) pulmonary TB cases. Conclusion: The mean annual successful treatment outcome is 75.3(±8.8) %. Female, pediatric, EPTB, new, and relapsed patients were predisposed to successful treatment outcomes. Lessons learned will guide future program modifications.

Suggested Citation

  • Michael A Alao & Stacene R Maroushek & Yiong Huak Chan & Adanze O Asinobi & Tina M Slusher & Daniel A Gbadero, 2020. "Treatment outcomes of Nigerian patients with tuberculosis: A retrospective 25-year review in a regional medical center," PLOS ONE, Public Library of Science, vol. 15(10), pages 1-13, October.
    • Handle: RePEc:plo:pone00:0239225
    DOI: 10.1371/journal.pone.0239225
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