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The correlation between proinsulin, true insulin, proinsulin: True insulin ratio, 25(OH) D3, waist circumference and risk of prediabetes in Hainan Han adults

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  • Huibiao Quan
  • Tuanyu Fang
  • Leweihua Lin
  • Lu Lin
  • Qianying Ou
  • Huachuan Zhang
  • Kaining Chen
  • Zhiguang Zhou

Abstract

Purpose: Diabetes mellitus is a kind of highly prevalent chronic disease in the world. The intervention measures on the risk factors of prediabetes contribute to control and reduce the occurrence of diabetes. This study aimed to investigate the correlation between proinsulin (PI), true insulin (TI), PI/TI, 25(OH) D3, waist circumference (WC), and risk of prediabetes. Methods: In this cross-sectional study, 1662 subjects including 615 prediabetes and 1047 non-prediabetes were recruited. Spearman’s correlation analysis was used to explore the association of PI, TI, PI/TI, 25(OH) D3, and waist circumference with prediabetes. Odds ratios (OR) and 95% confidence intervals (CI) were calculated by logistic regression. Receiver-Operator Characteristic (ROC) curve was used to evaluate the risk of prediabetes. Results: Our study showed that FPI, 2hPI, FTI, 2hTI, FPI/FTI, and WC could enhance the risk of prediabetes (OR 1.034; OR 1.007; OR 1.005; OR 1.002; OR 3.577, OR 1.053, respectively; all p

Suggested Citation

  • Huibiao Quan & Tuanyu Fang & Leweihua Lin & Lu Lin & Qianying Ou & Huachuan Zhang & Kaining Chen & Zhiguang Zhou, 2020. "The correlation between proinsulin, true insulin, proinsulin: True insulin ratio, 25(OH) D3, waist circumference and risk of prediabetes in Hainan Han adults," PLOS ONE, Public Library of Science, vol. 15(9), pages 1-13, September.
    • Handle: RePEc:plo:pone00:0238095
    DOI: 10.1371/journal.pone.0238095
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    1. Ling Lu & Derrick A Bennett & Iona Y Millwood & Sarah Parish & Mark I McCarthy & Anubha Mahajan & Xu Lin & Fiona Bragg & Yu Guo & Michael V Holmes & Shoaib Afzal & Børge G Nordestgaard & Zheng Bian & , 2018. "Association of vitamin D with risk of type 2 diabetes: A Mendelian randomisation study in European and Chinese adults," PLOS Medicine, Public Library of Science, vol. 15(5), pages 1-17, May.
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