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Morphologic analysis of macular neovascularizations by OCT angiography—Technical limitations in the comparison of 3×3mm and 6×6mm images

Author

Listed:
  • Henrik Faatz
  • Kai Rothaus
  • Marie-Louise Gunnemann
  • Marius Book
  • Pia Wilming
  • Matthias Gutfleisch
  • Georg Spital
  • Albrecht Lommatzsch
  • Daniel Pauleikhoff

Abstract

Background: The aim of this study was to ascertain whether there are relevant differences between the vascular morphology of macular neovascularizations (MNV) in 3×3mm and 6×6mm images, produced by optical coherence tomography angiography (OCTA). Methods: MNV of 49 patients were automated quantitative analysed, measuring area, flow, the fractal dimension, average vessel length, vascular density, and average vessel caliber. These parameters were compared between the 3×3mm and the 6×6mm images. Results: A strong linear association was found between the 3×3mm and the 6×6mm images. While area, flow, and FD of the MNV were very similar, the 3×3mm images showed significantly lower average total vessel length, greater vascular density, and lower average vessel caliber. Conclusion: In quantitative analysis of the morphologic parameters of MNV in 3×3mm and 6×6mm images, the structures are not directly equivalent in the two sizes of scan. The images must be evaluated on an individual basis.

Suggested Citation

  • Henrik Faatz & Kai Rothaus & Marie-Louise Gunnemann & Marius Book & Pia Wilming & Matthias Gutfleisch & Georg Spital & Albrecht Lommatzsch & Daniel Pauleikhoff, 2020. "Morphologic analysis of macular neovascularizations by OCT angiography—Technical limitations in the comparison of 3×3mm and 6×6mm images," PLOS ONE, Public Library of Science, vol. 15(8), pages 1-11, August.
    • Handle: RePEc:plo:pone00:0237785
    DOI: 10.1371/journal.pone.0237785
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