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Glecaprevir–pibrentasvir for chronic hepatitis C: Comparing treatment effect in patients with and without end-stage renal disease in a real-world setting

Author

Listed:
  • Hsu-Heng Yen
  • Pei-Yuan Su
  • Ya-Huei Zeng
  • I-Ling Liu
  • Siou-Ping Huang
  • Yu-Chun Hsu
  • Yang-Yuan Chen
  • Chia-Wei Yang
  • Shun-Sheng Wu
  • Kun-Ching Chou

Abstract

Introduction: Chronic hepatitis C virus (HCV) infection is increasingly observed in patients with renal disease. With the introduction of glecaprevir/pibrentasvir (GLE/PIB) as a pan-genotype therapy for HCV, treatment efficacy is expected to rise. Materials and methods: This retrospective study evaluated the efficacy and safety of GLE/PIB treatment in adults with HCV infection and end-stage renal disease (ESRD). The primary end point was sustained virological response (SVR) observed 12 weeks after completed treatment. Results: We enrolled 235 patients, including 44 patients with ESRD. Median age was 60 years, and 48% were males. Twenty-two percent had cirrhosis. HCV genotypes 1 (43%) and 2 (41%) were the most common. The overall SVR rate was 96.6%. Patients with ESRD were older than those without (67.6 years vs 58.3 years, p

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  • Hsu-Heng Yen & Pei-Yuan Su & Ya-Huei Zeng & I-Ling Liu & Siou-Ping Huang & Yu-Chun Hsu & Yang-Yuan Chen & Chia-Wei Yang & Shun-Sheng Wu & Kun-Ching Chou, 2020. "Glecaprevir–pibrentasvir for chronic hepatitis C: Comparing treatment effect in patients with and without end-stage renal disease in a real-world setting," PLOS ONE, Public Library of Science, vol. 15(8), pages 1-10, August.
    • Handle: RePEc:plo:pone00:0237582
    DOI: 10.1371/journal.pone.0237582
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