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Serum uromodulin is inversely associated with arterial hypertension and the vasoconstrictive prohormone CT-proET-1 in the population-based KORA F4 study

Author

Listed:
  • Cornelia Then
  • Barbara Thorand
  • Holger L Then
  • Christa Meisinger
  • Margit Heier
  • Annette Peters
  • Wolfgang Koenig
  • Wolfgang Rathmann
  • Martin Bidlingmaier
  • Andreas Lechner
  • Martin Reincke
  • Jürgen E Scherberich
  • Jochen Seissler

Abstract

Objectives: Uromodulin has been associated with arterial hypertension in genome-wide association studies, but data from clinical and preclinical studies are inconsistent. We here analyzed the association of serum uromodulin (sUmod) with arterial hypertension and vasoactive hormones in a population-based study. Methods: In 1108 participants of the KORA F4 study aged 62–81 years, sUmod was measured and the association of sUmod with arterial hypertension was assessed using logistic regression models. The associations of sUmod with renin and aldosterone and with the vasoconstrictive prohormone C-terminal pro-endothelin-1 (CT-proET-1) were analyzed in 1079 participants and in 618 participants, respectively, using linear regression models. Results: After multivariable adjustment including sex, age, eGFR, BMI, fasting glucose, current smoking, previous stroke and myocardial infarction, sUmod was inversely associated with arterial hypertension (OR 0.78; 95% CI 0.68–0.91; p = 0.001). SUmod was not significantly associated with renin and aldosterone after adjustment for sex, age and eGFR. However, sUmod was inversely associated with CT-proET-1 (β -0.19 ± 0.04; p

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  • Cornelia Then & Barbara Thorand & Holger L Then & Christa Meisinger & Margit Heier & Annette Peters & Wolfgang Koenig & Wolfgang Rathmann & Martin Bidlingmaier & Andreas Lechner & Martin Reincke & Jür, 2020. "Serum uromodulin is inversely associated with arterial hypertension and the vasoconstrictive prohormone CT-proET-1 in the population-based KORA F4 study," PLOS ONE, Public Library of Science, vol. 15(8), pages 1-12, August.
    • Handle: RePEc:plo:pone00:0237364
    DOI: 10.1371/journal.pone.0237364
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    References listed on IDEAS

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    1. Sandosh Padmanabhan & Olle Melander & Toby Johnson & Anna Maria Di Blasio & Wai K Lee & Davide Gentilini & Claire E Hastie & Cristina Menni & Maria Cristina Monti & Christian Delles & Stewart Laing & , 2010. "Genome-Wide Association Study of Blood Pressure Extremes Identifies Variant near UMOD Associated with Hypertension," PLOS Genetics, Public Library of Science, vol. 6(10), pages 1-11, October.
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