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Left ventricular non-compaction as a potential source for cryptogenic ischemic stroke in the young: A case-control study

Author

Listed:
  • Pauli Pöyhönen
  • Jouni Kuusisto
  • Vesa Järvinen
  • Jani Pirinen
  • Heli Räty
  • Lauri Lehmonen
  • Riitta Paakkanen
  • Nicolas Martinez-Majander
  • Jukka Putaala
  • Juha Sinisalo

Abstract

Background: Up to 50% of ischemic strokes in the young after thorough diagnostic work-up remain cryptogenic or associated with low-risk sources of cardioembolism such as patent foramen ovale (PFO). We studied with cardiac magnetic resonance (CMR) imaging, whether left ventricular (LV) non-compaction—a possible source for embolic stroke due to sluggish blood flow in deep intertrabecular recesses—is associated with cryptogenic strokes in the young. Methods: Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Etiology, Triggers, and Outcome (SECRETO; NCT01934725) is an international prospective multicenter case-control study of young adults (aged 18–49 years) presenting with an imaging-positive first-ever ischemic stroke of undetermined etiology. In this pilot substudy, 30 cases and 30 age- and sex-matched stroke-free controls were examined with CMR. Transcranial Doppler (TCD) bubble test was performed to evaluate the presence and magnitude of right-to-left shunt (RLS). Results: There were no significant differences in LV volumes, masses or systolic function between cases and controls; none of the participants had non-compaction cardiomyopathy. Semi-automated assessment of LV non-compaction was highly reproducible. Non-compacted LV mass (median 14.0 [interquartile range 12.6–16.0] g/m2 vs. 12.7 [10.4–16.6] g/m2, p = 0.045), the ratio of non-compacted to compacted LV mass (mean 25.6 ± 4.2% vs. 22.8 ± 6.0%, p = 0.015) and the percentage of non-compacted LV volume (mean 17.6 ± 2.9% vs. 15.7 ± 3.8%, p = 0.004) were higher in cases compared to controls. In a multivariate conditional logistic regression model including non-compacted LV volume, RLS and body mass index, the percentage of non-compacted LV volume (odds ratio [OR] 1.55, 95% confidence interval [CI] 1.10–2.18, p = 0.011) and the presence of RLS (OR 11.94, 95% CI 1.14–124.94, p = 0.038) were independently associated with cryptogenic ischemic stroke. Conclusions: LV non-compaction is associated with a heightened risk of cryptogenic ischemic stroke in young adults, independent of concomitant RLS and in the absence of cardiomyopathy. Clinical trial registration: SECRETO; NCT01934725. Registered 4th September 2013. https://clinicaltrials.gov/ct2/show/NCT01934725

Suggested Citation

  • Pauli Pöyhönen & Jouni Kuusisto & Vesa Järvinen & Jani Pirinen & Heli Räty & Lauri Lehmonen & Riitta Paakkanen & Nicolas Martinez-Majander & Jukka Putaala & Juha Sinisalo, 2020. "Left ventricular non-compaction as a potential source for cryptogenic ischemic stroke in the young: A case-control study," PLOS ONE, Public Library of Science, vol. 15(8), pages 1-13, August.
    • Handle: RePEc:plo:pone00:0237228
    DOI: 10.1371/journal.pone.0237228
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