IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0233500.html
   My bibliography  Save this article

The perceived impact of isoniazid resistance on outcome of first-line rifampicin-throughout regimens is largely due to missed rifampicin resistance

Author

Listed:
  • Armand Van Deun
  • Tom Decroo
  • Aung Kya Jai Maug
  • Mohamed Anwar Hossain
  • Murid Gumusboga
  • Wim Mulders
  • Nimer Ortuño-Gutiérrez
  • Lutgarde Lynen
  • Bouke C de Jong
  • Hans L Rieder

Abstract

Background: Meta-analyses on impact of isoniazid-resistant tuberculosis informed the World Health Organization recommendation of a levofloxacin-strengthened rifampicin-based regimen. Methods: Retrospective analysis of 7291 treatment episodes with known initial isoniazid and rifampicin status obtained from individual patient databases maintained by the Damien Foundation Bangladesh over 20 years. Drug susceptibility test results were confirmed by the programme’s designated supra-national tuberculosis laboratory. To detect missed Rr among isolates routinely classified as Hr, rpoB gene sequencing was done randomly and on a sample selected for suspected missed Rr. Results: Initial Hr caused a large recurrence excess after the 8-month regimen for new cases (rifampicin for two months), but had little impact on rifampicin-throughout regimens: (6 months, new cases; 3.8%; OR 0.8, 95%CI:0.3,2.8; 8 months, retreatment cases: 7.3%, OR 1.8; 95%CI:1.3,2.6). Rr was missed in 7.6% of randomly selected "Hr" strains. Acquired Rr was frequent among recurrences on rifampicin-throughout regimens, particularly after the retreatment regimen (31.9%). It was higher in mono-Hr (29.3%; aOR 3.5, 95%CI:1.5,8.5) and poly-Hr (53.3%; aOR 10.2, 95%CI 4.4,23.7) than in susceptible tuberculosis, but virtually absent after the 8-month new case regimen. Comparing Bangladesh (low Rr prevalence) with a high Rr prevalence setting,true Hr corrected for missed Rr caused only 2–3 treatment failures per 1000 TB cases (of whom 27% were retreatments) in both. Conclusions: Our analysis reveals a non-negligible extent of misclassifying as isoniazid resistance of what is actually missed multidrug-resistant tuberculosis. Recommending for such cases a “strengthened” regimen containing a fluoroquinolone provokes a direct route to extensive resistance while offering little benefit against the minor role of true Hr tuberculosis in rifampicin-throughout first-line regimen.

Suggested Citation

  • Armand Van Deun & Tom Decroo & Aung Kya Jai Maug & Mohamed Anwar Hossain & Murid Gumusboga & Wim Mulders & Nimer Ortuño-Gutiérrez & Lutgarde Lynen & Bouke C de Jong & Hans L Rieder, 2020. "The perceived impact of isoniazid resistance on outcome of first-line rifampicin-throughout regimens is largely due to missed rifampicin resistance," PLOS ONE, Public Library of Science, vol. 15(5), pages 1-18, May.
    • Handle: RePEc:plo:pone00:0233500
    DOI: 10.1371/journal.pone.0233500
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233500
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0233500&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0233500?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Anonymous, 1964. "World Health Organization," International Organization, Cambridge University Press, vol. 18(4), pages 859-870, October.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Alan Barreca & Karen Clay & Joel Tarr, 2014. "Coal, Smoke, and Death: Bituminous Coal and American Home Heating," NBER Working Papers 19881, National Bureau of Economic Research, Inc.
    2. Fazli Wahid & Dr.Sajjad Ali & Jan Muhammad, 2021. "Effective Sources of Information in Winter Seasonal Diseases: The Perception of Residents of District Buner, KP," Journal of Media & Communication (JMC), Ilma University, Faculty of Media & Design, vol. 1(2), pages 215-229.
    3. Allison Tatarsky & Shahina Aboobakar & Justin M Cohen & Neerunjun Gopee & Ambicadutt Bheecarry & Devanand Moonasar & Allison A Phillips & James G Kahn & Bruno Moonen & David L Smith & Oliver Sabot, 2011. "Preventing the Reintroduction of Malaria in Mauritius: A Programmatic and Financial Assessment," PLOS ONE, Public Library of Science, vol. 6(9), pages 1-11, September.
    4. Brimnes, Niels, 2008. "BCG vaccination and WHO's global strategy for tuberculosis control 1948-1983," Social Science & Medicine, Elsevier, vol. 67(5), pages 863-873, September.
    5. Nelly Katharina Manurung & Ngena Ria & Susy Adrianelly Simaremare, 2020. "The Association Between the Knowledge of Oral Hygiene of Mothers Who Chewing Betel Leaves and Their Oral Condition in Lingkungan II Lau Cih, Medan Tuntungan," Global Journal of Health Science, Canadian Center of Science and Education, vol. 12(9), pages 145-145, August.
    6. T Alex Perkins & Thomas W Scott & Arnaud Le Menach & David L Smith, 2013. "Heterogeneity, Mixing, and the Spatial Scales of Mosquito-Borne Pathogen Transmission," PLOS Computational Biology, Public Library of Science, vol. 9(12), pages 1-16, December.
    7. Christophe Drouet, 2020. "Nanotechnologies- A Key Role in Virus Fight," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 27(2), pages 20774-20782, May.
    8. Sharon Sherry Huang & Erick Ceasar Huang & Chao Shen Huang, 2018. "The Advancements in the Early Detection of Zika Virus Infection," Global Journal of Health Science, Canadian Center of Science and Education, vol. 10(10), pages 1-30, October.
    9. Tihansky, Dennis P., 1973. "An Economic Assessment of Marine Water Pollution Damages," File Manuscripts, United States National Marine Fisheries Service, Economic Research Division, number 233636.
    10. Carlos Bozzoli & Angus Deaton & Climent Quintana-Domeque, 2009. "Adult height and childhood disease," Demography, Springer;Population Association of America (PAA), vol. 46(4), pages 647-669, November.
    11. Mortimer Spiegelman, 1965. "Mortality Trends For Causes Of Death In Countries Of Low Mortality," Demography, Springer;Population Association of America (PAA), vol. 2(1), pages 115-125, March.
    12. Selvam Kannathasan & Arumugam Murugananthan & Nadarajah Rajeshkannan & Nilanthy Renuka de Silva, 2012. "Cutaneous Larva Migrans among Devotees of the Nallur Temple in Jaffna, Sri Lanka," PLOS ONE, Public Library of Science, vol. 7(1), pages 1-5, January.
    13. Stephan Karl & Michael T White & George J Milne & David Gurarie & Simon I Hay & Alyssa E Barry & Ingrid Felger & Ivo Mueller, 2016. "Spatial Effects on the Multiplicity of Plasmodium falciparum Infections," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-20, October.
    14. Peter Greenspoon & Donald Saklofske, 2001. "Toward an Integration of Subjective Well-Being and Psychopathology," Social Indicators Research: An International and Interdisciplinary Journal for Quality-of-Life Measurement, Springer, vol. 54(1), pages 81-108, April.
    15. Åshild Wik Despriee & Eva Langeland, 2016. "The effect of sucrose as pain relief/comfort during immunisation of 15‐month‐old children in health care centres: a randomised controlled trial," Journal of Clinical Nursing, John Wiley & Sons, vol. 25(3-4), pages 372-380, February.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0233500. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.