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Effectiveness of sofosbuvir based direct-acting antiviral regimens for chronic hepatitis C virus genotype 6 patients: Real-world experience in Vietnam

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  • Dung Thanh Nguyen
  • Thanh Thi Thanh Tran
  • Ngoc My Nghiem
  • Phuong Thanh Le
  • Quang Minh Vo
  • Jeremy Day
  • Motiur Rahman
  • Hung Mạnh Le

Abstract

Background: Hepatitis C virus (HCV) genotype 6 is the commonest cause of chronic hepatitis C infection in much of southeast Asia, but data on the effectiveness of direct-acting antiviral agents (DAAs) against this genotype are limited. We conducted a retrospective cohort study of patients attending the Hospital for Tropical Diseases (HTD), Ho Chi Minh City, Vietnam, to define the effectiveness of DAAs in the treatment of chronic HCV genotype 6 in actual practice. Methods: We included all patients with genotype 6 infections attending our hospital between March 2016 and October 2017 who received treatment with sofosbuvir-based DAA treatment regimens, and compared their responses with those with genotype 1 infections. Results: 1758 patients (1148 genotype 6, 65.4%; 610 genotype 1, 34.6%) were analyzed. The majority of patients (1480, 84.2%) received sofosbuvir/ledipasvir (SOF/LDV) ± ribavirin (RBV); 278 (15.8%) received sofosbuvir/Daclatasvir (SOF/DCV) ± RBV. The median age of the patients was 57 years, (interquartile range (IQR) 46–64 years) The baseline HCV viral load (log IU/ml) was significantly higher in patients infected with genotype 6 compared with those infected with genotype 1 (6.8, 5.3–6.6 versus 6.3, 5.3–6.5 log10 IU/ml, p =

Suggested Citation

  • Dung Thanh Nguyen & Thanh Thi Thanh Tran & Ngoc My Nghiem & Phuong Thanh Le & Quang Minh Vo & Jeremy Day & Motiur Rahman & Hung Mạnh Le, 2020. "Effectiveness of sofosbuvir based direct-acting antiviral regimens for chronic hepatitis C virus genotype 6 patients: Real-world experience in Vietnam," PLOS ONE, Public Library of Science, vol. 15(5), pages 1-16, May.
    • Handle: RePEc:plo:pone00:0233446
    DOI: 10.1371/journal.pone.0233446
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