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Indexation of left ventricular mass to predict adverse clinical outcomes in pre-dialysis patients with chronic kidney disease: KoreaN cohort study of the outcome in patients with chronic kidney disease

Author

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  • Sung Woo Lee
  • Hyang Ki Min
  • Dong-Wan Chae
  • Kook-Hwan Oh
  • Curie Ahn
  • Wookyung Chung
  • Joongyub Lee
  • Yong-Soo Kim
  • Su Ah Sung
  • Representing the KNOW-CKD Study Group

Abstract

Background: No study has compared the clinical impact of indexation of left ventricular mass (LVM) on adverse clinical outcomes in pre-dialysis patients with chronic kidney disease (CKD). Methods: We reviewed 2,101 patients from a large-scale multi-center prospective study that gathered anthropometric and echocardiographic measurements and clinical outcomes. The LVM was indexed as body surface area (LVMI-BSA) and height raised to the power of 2.7 (LVMI-H2.7). The main outcomes were composite renal and cardiovascular events and all-cause mortality. Left ventricular hypertrophy (LVH) was defined as the highest sex-specific quartile of LVMI-BSA or LVMI-H2.7. Results: During a mean period of 3.5 years, 692 patients developed composite outcomes (32.9%). The area under the curve at 5 year of LVM (60.6%) for composite outcome was smaller than that for LVMI-BSA (63.2%, P

Suggested Citation

  • Sung Woo Lee & Hyang Ki Min & Dong-Wan Chae & Kook-Hwan Oh & Curie Ahn & Wookyung Chung & Joongyub Lee & Yong-Soo Kim & Su Ah Sung & Representing the KNOW-CKD Study Group, 2020. "Indexation of left ventricular mass to predict adverse clinical outcomes in pre-dialysis patients with chronic kidney disease: KoreaN cohort study of the outcome in patients with chronic kidney diseas," PLOS ONE, Public Library of Science, vol. 15(5), pages 1-14, May.
    • Handle: RePEc:plo:pone00:0233310
    DOI: 10.1371/journal.pone.0233310
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