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Measurement of normal retinal vascular pulse wave attenuation using modified photoplethysmography

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  • Anmar Abdul-Rahman
  • William Morgan
  • Dao-Yi Yu

Abstract

Pulse wave attenuation characteristics reflect compliance and resistance properties of the vessel wall as well as initial pulse generation factors. Recently, it has become possible to measure and map the retinal vessel wall pulse wave amplitudes. Predictable pulse wave amplitude distribution may allow inferences to be made concerning vascular compliance and resistance. Twenty-eight eyes from sixteen subjects (8 male and 8 female) were examined using modified retinal photoplethysmography with simultaneous ophthalmodynamometry. This allowed the assessment of vessel wall pulsation amplitudes under a dynamic range of intraocular pressures. Pulse amplitudes were calculated using harmonic regression analysis. The pulse wave attenuation was measured under different ranges of ophthalmodynamometric force (ODF) as a function of distance along the vessel (VDist), which in turn was calculated in disc diameters (DD) from the center of the optic disc. A linear mixed-effects model with randomized slopes and intercepts was used to estimate the correlations between the logarithmically transformed harmonic regression wave amplitude (HRWa) and the Fourier trigonometric coefficients with the predictors (VDist and ODF). The retinal venous harmonic regression wave attenuation (coefficient value±standard error) -0.40±0.065/DD, (p-value

Suggested Citation

  • Anmar Abdul-Rahman & William Morgan & Dao-Yi Yu, 2020. "Measurement of normal retinal vascular pulse wave attenuation using modified photoplethysmography," PLOS ONE, Public Library of Science, vol. 15(5), pages 1-28, May.
    • Handle: RePEc:plo:pone00:0232523
    DOI: 10.1371/journal.pone.0232523
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