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Evidence of rotavirus vaccine impact in sub-Saharan Africa: Systematic review and meta-analysis

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  • Opolot Godfrey
  • Weidong Zhang
  • Cecilia Amponsem-Boateng
  • Timothy Bonney Oppong
  • QingLin Zhao
  • Dankang Li

Abstract

Background: Over 34 countries in Africa have introduced rotavirus vaccine to their national immunization programs: monovalent (Rotarix®, RV1) and pentavalent (RotaTeq®, RV5) after South Africa introduced it in 2009. Since then several studies assessing the impact of the vaccine have been conducted. The principal aim of this study was to evaluate the impact of rotavirus vaccine in sub-Saharan Africa. Methods: A Literature search was performed using Mendeley, PubMed, ScienceDirect, grey literature and Web of Science databases of published studies from January 1, 2017, as years of recent publications on rotavirus vaccine impact in sub-Saharan Africa. A meta-analysis was conducted for rotavirus infection in children under 5 years using proportions of pre and post-vaccine introduction in these populations. Random-effect estimates were considered since the samples were from universal populations. Results: Out of the 935 articles identified, 17 studies met the inclusion for systematic review and meta-analysis. The pooled proportion for pre-vaccination period was 42%, 95% (CI: 38–46%), and reduced to 21%, 95% (CI: 17–25%) during post-vaccination period. Rotavirus diarrhea significantly reduced in children

Suggested Citation

  • Opolot Godfrey & Weidong Zhang & Cecilia Amponsem-Boateng & Timothy Bonney Oppong & QingLin Zhao & Dankang Li, 2020. "Evidence of rotavirus vaccine impact in sub-Saharan Africa: Systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 15(4), pages 1-13, April.
    • Handle: RePEc:plo:pone00:0232113
    DOI: 10.1371/journal.pone.0232113
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