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Association of early viral lower respiratory infections and subsequent development of atopy, a systematic review and meta-analysis of cohort studies

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  • Sebastien Kenmoe
  • Cyprien Kengne-Nde
  • Abdou Fatawou Modiyinji
  • Jean Joel Bigna
  • Richard Njouom

Abstract

Introduction: Existing evidence on the relationship between childhood lower respiratory tract infections (LRTI) and the subsequent atopy development is controversial. We aimed to investigate an association between viral LRTI at 2 years. Methods: We conducted a search at Embase, Pubmed, Web of Science, and Global Index Medicus. We collected data from the included articles. We estimated the odds ratio and the 95% confidence intervals with a random effect model. We determined factors associated with atopy development after childhood LRTI using univariate and multivariate meta-regression analyses. We recorded this systematic review at PROSPERO with the number CRD42018116955. Results: We included 24 studies. There was no relationship between viral LRTI at

Suggested Citation

  • Sebastien Kenmoe & Cyprien Kengne-Nde & Abdou Fatawou Modiyinji & Jean Joel Bigna & Richard Njouom, 2020. "Association of early viral lower respiratory infections and subsequent development of atopy, a systematic review and meta-analysis of cohort studies," PLOS ONE, Public Library of Science, vol. 15(4), pages 1-15, April.
    • Handle: RePEc:plo:pone00:0231816
    DOI: 10.1371/journal.pone.0231816
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