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Serial changes of renal function after directly acting antivirals treatment for chronic hepatitis C: A 1-year follow-up study after treatment

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Listed:
  • Shao-Ming Chiu
  • Ming-Chao Tsai
  • Chun-Yen Lin
  • Chien-Hung Chen
  • Sheng-Nan Lu
  • Chao-Hung Hung
  • I-Shyan Sheen
  • Rong-Nan Chien
  • Chih-Lang Lin
  • Tsung-Hui Hu
  • Yu-Fan Cheng
  • Chao-Long Chen

Abstract

Background: Our preliminary data showed a slight decrease of estimated glomerular filtration rate (eGFR) after direct-acting antivirals (DAAs) treatment in chronic hepatitis C (CHC). However, long-term outcome of renal evolution after DAAs has not been well documented. Aim: To assess the renal function under DAAs treatment in CHC patients of an Asian population at 6 months and 1 year after complete treatment. Methods: A cohort of 1536 CHC patients who received therapies with DAAs were analyzed. Serial eGFR levels at 24 weeks after treatment (SVR24) and 48 weeks after treatment (SVR48) were evaluated. We compared eGFR at baseline, SVR12, SVR24 and SVR48, and defined renal function deterioration as decrease of eGFR >25% from baseline to SVR24 and SVR48. Results: Overall, there was decline of eGFR from SVR12 to SVR48 in all patients (84.30 ± 27.00 -> 73.20 ± 28.67 mL/min/1.73m2, p

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  • Shao-Ming Chiu & Ming-Chao Tsai & Chun-Yen Lin & Chien-Hung Chen & Sheng-Nan Lu & Chao-Hung Hung & I-Shyan Sheen & Rong-Nan Chien & Chih-Lang Lin & Tsung-Hui Hu & Yu-Fan Cheng & Chao-Long Chen, 2020. "Serial changes of renal function after directly acting antivirals treatment for chronic hepatitis C: A 1-year follow-up study after treatment," PLOS ONE, Public Library of Science, vol. 15(4), pages 1-14, April.
    • Handle: RePEc:plo:pone00:0231102
    DOI: 10.1371/journal.pone.0231102
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