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Higher thresholds for the utilization of steatotic allografts in liver transplantation: Analysis from a U.S. national database

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  • Justin A Steggerda
  • Matthew B Bloom
  • Mazen Noureddin
  • Todd V Brennan
  • Tsuyoshi Todo
  • Nicholas N Nissen
  • Andrew S Klein
  • Irene K Kim

Abstract

Background: Historically, liver allografts with >30% macrosteatosis (MaS) on donor biopsy have been associated with early allograft dysfunction and worse graft survival; however, successful outcomes have been reported in small cohorts. This study proposes an elevated MaS threshold for organ utilization without detriment to graft survival. Methods: The UNOS Standard Transplant Analysis and Research database was evaluated for transplants between 2006–2015. Graft survival up to 1-year was evaluated by Kaplan-Meier (KM) survival analyses, and by univariate and multivariable logistic regression analyses, including donor and recipient characteristics. Odds ratios (OR) with 95% confidence intervals (CI) for risk of graft loss are reported. Results: Thirty-day risk of graft loss was increased with MaS as low as 10–19% (OR [95% CI] 1.301 [1.055–1.605], p

Suggested Citation

  • Justin A Steggerda & Matthew B Bloom & Mazen Noureddin & Todd V Brennan & Tsuyoshi Todo & Nicholas N Nissen & Andrew S Klein & Irene K Kim, 2020. "Higher thresholds for the utilization of steatotic allografts in liver transplantation: Analysis from a U.S. national database," PLOS ONE, Public Library of Science, vol. 15(4), pages 1-17, April.
    • Handle: RePEc:plo:pone00:0230995
    DOI: 10.1371/journal.pone.0230995
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