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Aspects of diastolic dysfunction in patients with new and recurrent depression

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  • Mariana Tudoran
  • Cristina Tudoran
  • Tudor Ciocarlie
  • Catalina Giurgi-Oncu

Abstract

Objective: The main objective of this study was to evidence the potential impact of the intensity, duration and recurrence of depression on the development of arterial stiffness (AS) leading to left ventricular hypertrophy (LVH) and diastolic dysfunction (DD) in patients with new onset depression (NOD) and recurrent depression (RD) in comparison to 33 control subjects without depression. Another aim was to identify potential predictive factors regarding the occurrence of diastolic dysfunction (DD). Methods: Our study group included 58 patients diagnosed with NOD and 128 diagnosed with RD, without any previously diagnosed significant heart diseases. The intensity of depression was evaluated by means of the Montgomery-Asberg Depression Rating Scale (MADRS). Assessment of pulse wave velocity (PWV), left ventricular mass index (LVMI) and echocardiographic parameters characterizing DD were performed for each patient. Results: The cardiology evaluations suggested an increased prevalence of AS in all patients, of significantly higher rate than in controls (p

Suggested Citation

  • Mariana Tudoran & Cristina Tudoran & Tudor Ciocarlie & Catalina Giurgi-Oncu, 2020. "Aspects of diastolic dysfunction in patients with new and recurrent depression," PLOS ONE, Public Library of Science, vol. 15(1), pages 1-10, January.
    • Handle: RePEc:plo:pone00:0228449
    DOI: 10.1371/journal.pone.0228449
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