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Vitreous levels of Lipocalin-2 on patients with primary rhegmatogenous retinal detachment

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  • Georgios Batsos
  • Eleni Christodoulou
  • Georgios Vartholomatos
  • Petros Galanis
  • Maria Stefaniotou

Abstract

Purpose: To measure vitreous levels of Lipocalin2 (LCN2) in patients with rhegmatogenous retinal detachment (RRD) and investigate potential association with presence of proliferative vitreoretinopathy (PVR). Materials and methods: Collection of undiluted vitreous samples from 24 patients suffering from RRD and 10 control patients undergoing vitrectomy for: vitreomacular traction (VMT) (n = 2), idiopathic epiretinal membrane (iERM) (n = 6) and full thickness macular hole (FTMH) (n = 2). Quantitative analysis of LCN2 has been made with flow cytometry. Lens status, duration of symptoms, quadrants of detachment, as well as level of PVR, were assessed. Statistical analysis included Mann-Whitney test, Kruskal-Wallis test, t-test, Spearman’s correlation coefficient and Fisher's exact test. Results: Median LCN2 was significantly higher in the RRD group as compared to control (p 2 quadrants, p

Suggested Citation

  • Georgios Batsos & Eleni Christodoulou & Georgios Vartholomatos & Petros Galanis & Maria Stefaniotou, 2019. "Vitreous levels of Lipocalin-2 on patients with primary rhegmatogenous retinal detachment," PLOS ONE, Public Library of Science, vol. 14(12), pages 1-9, December.
    • Handle: RePEc:plo:pone00:0227266
    DOI: 10.1371/journal.pone.0227266
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