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Genes associated with body weight gain and feed intake identified by meta-analysis of the mesenteric fat from crossbred beef steers

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  • Amanda K Lindholm-Perry
  • Harvey C Freetly
  • William T Oliver
  • Lea A Rempel
  • Brittney N Keel

Abstract

Mesenteric fat is a visceral fat depot that increases with cattle maturity and can be influenced by diet. There may be a relationship between the accumulation of mesenteric fat and feed efficiency in beef cattle. The purpose of this study was to identify genes that may be differentially expressed in steers with high and low BW gain and feed intake. RNA-Seq was used to evaluate the transcript abundance of genes in the mesenteric fat from a total of 78 steers collected over 5 different cohorts. A meta-analysis was used to identify genes involved with gain, feed intake or the interaction of both phenotypes. The interaction analysis identified 11 genes as differentially expressed. For the main effect of gain, a total of 87 differentially expressed genes (DEG) were identified (PADJ

Suggested Citation

  • Amanda K Lindholm-Perry & Harvey C Freetly & William T Oliver & Lea A Rempel & Brittney N Keel, 2020. "Genes associated with body weight gain and feed intake identified by meta-analysis of the mesenteric fat from crossbred beef steers," PLOS ONE, Public Library of Science, vol. 15(1), pages 1-15, January.
    • Handle: RePEc:plo:pone00:0227154
    DOI: 10.1371/journal.pone.0227154
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