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Prediction of early C-reactive protein levels after non-cardiac surgery under general anesthesia

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  • Shiroh Nakamoto
  • Munetaka Hirose

Abstract

Background: Early detection of postoperative increase in C-reactive protein (CRP) correlates with postoperative complications. The present study examined the association between preoperative / intraoperative factors and postoperative CRP levels, with development and validation of a prediction model of early postoperative CRP level, for prophylactic management of postoperative complications in patients undergoing surgery under general anesthesia. Material and methods: Multivariate regression analysis was retrospectively performed to determine the independent factor of CRP levels on postoperative day (POD) 1 and to develop a prediction model. Validation of the prediction model was prospectively performed. Data from 316 adult patients on perioperative variables were retrospectively obtained in a training cohort in patients undergoing elective non-cardiac surgery. In a validation cohort, 88 patients undergoing mastectomy and 68 patients undergoing laparoscopic colon surgery were prospectively utilized to evaluate the value of the prediction model. Major complications after surgery were defined as the Clavien-Dindo grade IIIa or greater. Results: Duration of surgery, mean nociceptive response (NR) during surgery as intraoperative nociception level, and preoperative CRP level were selected to set up the prediction model of CRP level on POD1 (P

Suggested Citation

  • Shiroh Nakamoto & Munetaka Hirose, 2019. "Prediction of early C-reactive protein levels after non-cardiac surgery under general anesthesia," PLOS ONE, Public Library of Science, vol. 14(12), pages 1-9, December.
    • Handle: RePEc:plo:pone00:0226032
    DOI: 10.1371/journal.pone.0226032
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