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Citric-acid dialysate improves the calcification propensity of hemodialysis patients: A multicenter prospective randomized cross-over trial

Author

Listed:
  • Karlien J ter Meulen
  • Marijke J E Dekker
  • Andreas Pasch
  • Natascha J H Broers
  • Frank M van der Sande
  • Jeroen B van der Net
  • Constantijn J A M Konings
  • Isabelle M Gsponer
  • Matthias D N Bachtler
  • Adelheid Gauly
  • Bernard Canaud
  • Jeroen P Kooman

Abstract

Introduction: The concentration of dialysate calcium (dCa) has been suggested to affect vascular calcification, but evidence is scarce. Calcification propensity reflects the intrinsic capacity of serum to prevent calcium and phosphate to precipitate. Methods: Chronic stable hemodialysis patients were included. This multicenter randomized cross-over study consisted out of a baseline week (A1.5), followed by the randomized sequence of A1.25 or C1.5 for one week after which the alternate treatment was provided after a washout week with A1.5. Calcification propensity of serum was assessed by time-resolved nephelometry where the T50 reflects the transition time between formation of primary and secondary calciprotein particles. Results: Eighteen patients (median age 70 years) completed the study. Intradialytic change in T50 was increased with C1.5 (121 [90–152]min) compared to A1.25 (83 [43–108]min, p

Suggested Citation

  • Karlien J ter Meulen & Marijke J E Dekker & Andreas Pasch & Natascha J H Broers & Frank M van der Sande & Jeroen B van der Net & Constantijn J A M Konings & Isabelle M Gsponer & Matthias D N Bachtler , 2019. "Citric-acid dialysate improves the calcification propensity of hemodialysis patients: A multicenter prospective randomized cross-over trial," PLOS ONE, Public Library of Science, vol. 14(12), pages 1-16, December.
    • Handle: RePEc:plo:pone00:0225824
    DOI: 10.1371/journal.pone.0225824
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