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A multicenter case control study of association of vitamin D with breast cancer among women in Karachi, Pakistan

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  • Uzma Shamsi
  • Shaista Khan
  • Iqbal Azam
  • Aysha Habib Khan
  • Amir Maqbool
  • Mohammad Hanif
  • Tiffany Gill
  • Romaina Iqbal
  • David Callen

Abstract

Background: The prevalence of vitamin D inadequacy and breast cancer are both high among women living in Karachi, Pakistan. Methods: A matched case control study was conducted in two hospitals of Karachi, Pakistan to evaluate the association of vitamin D (serum 25-hydroxyvitamin D) concentrations, vitamin D supplementation and sun exposure with breast cancer among Pakistani women. A total of 411 newly diagnosed histologically confirmed primary breast cancer cases were enrolled and 784 controls, free of breast and any other cancers, were matched by age (year of birth ± 5 years), residence in the same geographic area and study site. Information was collected on sociodemographic history, history of vitamin D supplementation, past medical and obstetrical history, family history of breast cancer, sun exposure history, histopathology reports and anthropometric measurement and venous blood was collected to measure serum 25-hydroxyvitamin D (25(OH)D) concentration. Results: Compared to patients with sufficient serum vitamin D (>30 ng/ml), women with serum vitamin D deficiency (

Suggested Citation

  • Uzma Shamsi & Shaista Khan & Iqbal Azam & Aysha Habib Khan & Amir Maqbool & Mohammad Hanif & Tiffany Gill & Romaina Iqbal & David Callen, 2020. "A multicenter case control study of association of vitamin D with breast cancer among women in Karachi, Pakistan," PLOS ONE, Public Library of Science, vol. 15(1), pages 1-21, January.
    • Handle: RePEc:plo:pone00:0225402
    DOI: 10.1371/journal.pone.0225402
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