IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0225327.html
   My bibliography  Save this article

The prognostic value of myeloid derived suppressor cell level in hepatocellular carcinoma: A systematic review and meta-analysis

Author

Listed:
  • Xinyu Zhang
  • Xin Fu
  • Tianyu Li
  • Huimin Yan

Abstract

Background and aims: Many studies have investigated the association between the level of myeloid derived suppressor cells (MDSCs) and clinical features and prognosis of hepatocellular carcinoma (HCC), but the results remain controversial. This systematic review and meta-analysis was conducted to summarize all available data and estimate the relationship. Methods: A comprehensive literature review was carried out using Medline, Embase and Web of Science database through December 2018 to identify relevant studies. The standardized mean difference (SMD) and the hazard ratio (HR) with 95% confidence interval (CI) were utilized for evaluating continuous outcomes and survival analysis, respectively. All statistical analyses were performed by STATA 14.0 software. Results: A total of 13 studies with 1002 HCC patients were included in the meta-analysis. Overall, the proportion of MDSCs in HCC patients was higher than that in healthy controls (SMD = 4.49, 95% CI = 2.53–6.46, P

Suggested Citation

  • Xinyu Zhang & Xin Fu & Tianyu Li & Huimin Yan, 2019. "The prognostic value of myeloid derived suppressor cell level in hepatocellular carcinoma: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 14(12), pages 1-13, December.
    • Handle: RePEc:plo:pone00:0225327
    DOI: 10.1371/journal.pone.0225327
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0225327
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0225327&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0225327?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Shuo Zhang & Xuelei Ma & Chenjing Zhu & Li Liu & Guoping Wang & Xia Yuan, 2016. "The Role of Myeloid-Derived Suppressor Cells in Patients with Solid Tumors: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-11, October.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Vincenzo Salemme & Mauro Vedelago & Alessandro Sarcinella & Federico Moietta & Alessio Piccolantonio & Enrico Moiso & Giorgia Centonze & Marta Manco & Andrea Guala & Alessia Lamolinara & Costanza Ange, 2023. "p140Cap inhibits β-Catenin in the breast cancer stem cell compartment instructing a protective anti-tumor immune response," Nature Communications, Nature, vol. 14(1), pages 1-22, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0225327. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.