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Obesity is associated with an impaired survival in lymphoma patients undergoing autologous stem cell transplantation

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  • Sebastian Scheich
  • Julius C Enßle
  • Victoria T Mücke
  • Fabian Acker
  • Lukas Aspacher
  • Sebastian Wolf
  • Anne C Wilke
  • Sarah Weber
  • Uta Brunnberg
  • Hubert Serve
  • Björn Steffen

Abstract

Autologous hematopoietic stem cell transplantation (auto-HSCT) provides a potentially curative treatment option for relapsed and refractory lymphomas. Obesity displays an emerging epidemic risk factor for global mortality and is associated with an increased mortality in cancer patients. To date, the impact of obesity on the outcome of lymphoma patients undergoing auto-HSCT is understudied. We conducted a retrospective single-center study assessing 119 lymphoma patients who underwent auto-HSCT. Overall survival (OS) served as the primary endpoint whereas progression free survival (PFS), cumulative incidence of non-relapse related mortality (NRM) and cumulative incidence of relapse were analyzed as secondary endpoints. Obese patients (Body mass index, BMI≥30) had significantly lower OS (45.3% vs. 77.9%; p = 0.005) and PFS (29.8% vs. 67.2%; p

Suggested Citation

  • Sebastian Scheich & Julius C Enßle & Victoria T Mücke & Fabian Acker & Lukas Aspacher & Sebastian Wolf & Anne C Wilke & Sarah Weber & Uta Brunnberg & Hubert Serve & Björn Steffen, 2019. "Obesity is associated with an impaired survival in lymphoma patients undergoing autologous stem cell transplantation," PLOS ONE, Public Library of Science, vol. 14(11), pages 1-14, November.
    • Handle: RePEc:plo:pone00:0225035
    DOI: 10.1371/journal.pone.0225035
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