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Vaginal progesterone to prevent preterm delivery among HIV-infected pregnant women in Zambia: A feasibility study

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  • Joan T Price
  • Winifreda M Phiri
  • Bethany L Freeman
  • Bellington Vwalika
  • Jennifer Winston
  • Chileshe M Mabula-Bwalya
  • Helen B Mulenga
  • Jeffrey S A Stringer

Abstract

Antenatal vaginal progesterone (VP) reduces the risk of preterm birth (PTB) in women with shortened cervical length, and we hypothesize that it may also prevent PTB in women with HIV as their primary risk factor. We conducted a pilot feasibility study in Lusaka, Zambia to investigate uptake, adherence, and retention in preparation for a future efficacy trial. This was a double-masked, placebo-controlled, randomized trial of 200mg daily self-administered VP suppository or placebo. Pregnant women with HIV who were initiating or continuing antiretroviral therapy were eligible for participation. Potential participants underwent ultrasound to assess eligibility; we excluded those ≥24 gestational weeks, with non-viable, multiple gestation, or extrauterine pregnancies, with short cervix (

Suggested Citation

  • Joan T Price & Winifreda M Phiri & Bethany L Freeman & Bellington Vwalika & Jennifer Winston & Chileshe M Mabula-Bwalya & Helen B Mulenga & Jeffrey S A Stringer, 2020. "Vaginal progesterone to prevent preterm delivery among HIV-infected pregnant women in Zambia: A feasibility study," PLOS ONE, Public Library of Science, vol. 15(1), pages 1-14, January.
    • Handle: RePEc:plo:pone00:0224874
    DOI: 10.1371/journal.pone.0224874
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