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Clinical features of pulmonary embolism in patients with lung cancer: A meta-analysis

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  • Xin Hua
  • Shu-Hua Han
  • Shu-Zhen Wei
  • Ying Wu
  • Jun Sha
  • Xiao-Li Zhu

Abstract

Background: Pulmonary embolism (PE) is correlated with increased mortality among patients with lung cancer (LC). The characteristics of patients with LC presenting with PE have not been fully established, and our meta-analysis aims to comprehensively investigate the clinical characteristics associated with PE in patients with LC to help physicians identify PE earlier in these patients. Methods: Multiple databases were searched, including PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure and Wanfang. Odds ratios (ORs) and weighted mean differences (WMDs) with 95% confidence intervals (95% CIs) were used as effect measures for dichotomous and continuous variables, respectively. Moreover, Egger’s test, Begg’s test and a sensitivity analysis were performed to assess the publication bias and reliability of the articles. Results: In total, 16 studies were included in our meta-analysis. The results indicated that history of chronic obstructive pulmonary disease (OR = 2.59, 95% CI: 1.09, 6.15; P = 0.03), adenocarcinoma (OR = 2.28, 95% CI: 1.88, 2.77; P

Suggested Citation

  • Xin Hua & Shu-Hua Han & Shu-Zhen Wei & Ying Wu & Jun Sha & Xiao-Li Zhu, 2019. "Clinical features of pulmonary embolism in patients with lung cancer: A meta-analysis," PLOS ONE, Public Library of Science, vol. 14(9), pages 1-13, September.
    • Handle: RePEc:plo:pone00:0223230
    DOI: 10.1371/journal.pone.0223230
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