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Clinical outcomes of bortezomib-based therapy in Taiwanese patients with multiple myeloma: A nationwide population-based study and a single-institute analysis

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  • Wei-Nung Liu
  • Chao-Feng Chang
  • Chi-Hsiang Chung
  • Wu-Chien Chien
  • Tzu-Chuan Huang
  • Yi-Ying Wu
  • Ching-Liang Ho
  • Jia-Hong Chen

Abstract

Purpose: In a retrospective cohort study, we report the current epidemiology of patients with multiple myeloma (MM) and analyze the real-world clinical outcomes of bortezomib-based therapy. Materials and methods: This retrospective study was mainly designed to evaluate the characteristics, treatment outcomes, and prognostic factors of patients with MM who received bortezomib-based therapy. We identified 5,726 patients in Taiwan with MM newly diagnosed between 2007 and 2015. Confidential data from the National Health Insurance Research Database (NHIRD) was used under strict guidelines, as it was made available in an electronic format for research purposes. In addition, we analyzed 96 patients who have been diagnosed with MM and were treated at the Tri-Service General Hospital (TSGH) between January 1, 2002, and December 31, 2018. Results: Patients receiving first-line treatment with bortezomib had longer overall survival (OS) compared to those who received non-first-line treatment (p

Suggested Citation

  • Wei-Nung Liu & Chao-Feng Chang & Chi-Hsiang Chung & Wu-Chien Chien & Tzu-Chuan Huang & Yi-Ying Wu & Ching-Liang Ho & Jia-Hong Chen, 2019. "Clinical outcomes of bortezomib-based therapy in Taiwanese patients with multiple myeloma: A nationwide population-based study and a single-institute analysis," PLOS ONE, Public Library of Science, vol. 14(9), pages 1-13, September.
    • Handle: RePEc:plo:pone00:0222522
    DOI: 10.1371/journal.pone.0222522
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