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Study on Dalfampridine in the treatment of Multiple Sclerosis Mobility Disability: A meta-analysis

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  • Jianzhen Shi
  • Xiaohui Wu
  • Yanmei Chen

Abstract

Objective: Systematic Review was used to evaluate the efficacy and safety of Dalfampridine (DAP) in the treatment of Mobility Disability (MS) in patients with Multiple Sclerosis. Methods: Clinical randomized controlled studies about DAP and placebo in the treatment of Mobility Disability in patients with Multiple Sclerosis until March 2019 were explored by searching Embase, PubMed, Cochrane, Web of Knowledge, and ClinicalTrials.gov. Literature screening, data extraction, quality assessment, and statistical analysis were performed by using Stata 14.0. Results: 10 papers were included in the meta-analysis, and the number of patients was 2100. In conclusion, the application of DAP in clinical can significantly improve the Mobility Disability of patients [OR = 2.73, 95%CI (1.66, 4.50), P 10 mg) is a litter higher than the placebo control group. Conclusion: DAP can effectively improve Mobility Disability in patients with Multiple Sclerosis, which is safe and reliable in specific DAP usage doses.

Suggested Citation

  • Jianzhen Shi & Xiaohui Wu & Yanmei Chen, 2019. "Study on Dalfampridine in the treatment of Multiple Sclerosis Mobility Disability: A meta-analysis," PLOS ONE, Public Library of Science, vol. 14(9), pages 1-13, September.
    • Handle: RePEc:plo:pone00:0222288
    DOI: 10.1371/journal.pone.0222288
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